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Researchers design new chemical “dye” to enhance liver cancer imaging

Researchers at the National University of Singapore have designed a new contrast agent based on nano diamond, a chemical “dye” utilized to improve the visibility of interior body arrangements in Magnetic Resonance Imaging, which advances visualization of tumors related to liver cancer. More sensitive and better scanning add in identifying liver cancer and are important for preparation of the treatment.

Magnetic Resonance Imaging is a medical scanning technology normally employed for diagnosis of cancer and to track the development of patients post therapy. Presently, there are 2 modes of Magnetic Resonance Imaging scanning, T2-weighted and T1-weighted imaging; and people are frequently provided with contrast agent to enhance quality of the scans. On the other hand, each mode of imaging needs a particular class of contrast agent that can’t be employed jointly. This creates a bigger challenge in the analysis of liver cancer, since T2-weighted scanning is still not believed as dependable and both T1- and T2-weighted scanning can be confused by vascularity of tumor.

Researchers design new chemical “dye” to enhance liver cancer imaging

A research squad headed by Edward Chow, Assistant Professor at Department of Pharmacology at NUS Yong Loo Lin of Medicine and Principal Investigator from the Cancer Science Institute of Singapore at NUS, has designed a twin-mode contrast agent that allows more accurate and clearer scans of tumors to be gained in both T1- and T2-weighted Magnetic Resonance Imaging scans, that too with lower contrast agent dosages.

The new twin-mode contrast agent, which was designed using nano diamonds in amalgamation with a base of manganese, offers better scanning contrast than current clinical agents that are utilized to enhance the quality of Magnetic Resonance Imaging. The squad also discovered that liver tumors that are not able to be visualized without contrast agents turn out to be readily visible even at small amounts of the new twin-mode contrast agent.

Contrast agents function by modifying the magnetic characteristics of nearby molecules of water, which improves the quality of Magnetic Resonance Imaging scans. Nano diamonds, which are carbon-produced particles of 2 to 8 Nanometres in diameter, have exceptional chemical characteristics that permit them to have magnetic effect on molecules of water. This allows them to encourage proton swap between paramagnetic ions and water molecules that mount up in tissues. Consequently, T1 and T2 recreation is improved, offering enhanced quality of images. This is unlike current approaches based on nanotechnology, where nano materials are utilized to enhance delivery of paramagnetic ions to particular tumor locations.

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