The brain is one of the most amazing creations. But once the brain starts to age, a lot of activities are hampered. According to a recent study, the scientist suggests that our brain starts aging at a significantly faster rate after hitting age 65 and possibly it even won’t depend on which allele of a specific gene is present.
Researchers, in recent years, have acknowledged several genes linked to Parkinson’s disease, Alzheimer’s disease, and other neurological disorders. However, those genes enlighten only a minute section of these disorders. As per the scientists, the key risk factor for such type of neurodegenerative disorder is aging. This is due to the changes taking place in the brain with aging which makes the individual more vulnerable to brain disease.
To find out the factor that controls brain aging, the scientist evaluated genetic data from almost 1,200 autopsied human brains from individuals were not detected with a neurodegenerative disorder while alive. From the study, they found a gene, TMEM106B, which drives the differential aging. TMEM106B is said to manage neuronal loss and inflammation in the brain. There are 2 alleles of the gene, one linked to the increased risk of brain aging, whereas as the other is found to defend such a speeding up of aging. The TMEM106B gene becomes active at about age 65. Shortly, the individual with a bad copy of this gene will have a brain that appears 10–12 years older than individuals of the similar age who have functioning copies.
The finding of the study can help the professionals to detect individuals who are at risk for such neurological diseases by having a defective TMEM106B gene. It can also aid in the development of drugs that can target the TMEM106B gene to support healthier brain aging.
So don’t you think TMEM106B gene can be an attractive target for scientists to develop therapies that can decelerate brain aging?